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HYPOCRELLIN, FROM HYPOCRELLA BAMBUASE , IS PHOTOTOXIC TO HUMAN IMMUNODEFICIENCY VIRUS
Author(s) -
Hudson J. B.,
Zhou J.,
Chen J.,
Harris L.,
Yip L.,
Towers G. H. N.
Publication year - 1994
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1994.tb05100.x
Subject(s) - hypericin , phototoxicity , perylene , human immunodeficiency virus (hiv) , virology , virus , pigment , chemistry , biology , microbiology and biotechnology , biochemistry , pharmacology , in vitro , organic chemistry , molecule
Hypocrellin, a photodynamic perylene quinonoid isolated from the Chinese medicinal fungus Hypocrella bambuase , was evaluated for antiviral activity against the human immunodeficiency virus (HIV‐1). Hypocrellin was phototoxic to HIV‐1, almost as good as the structurally similar plant pigment hypericin, and like hypericin its activity required visible light. In contrast peroxyhypocrellin had little or no effect on the virus.