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TUMOR‐LOCALIZING FLUORESCENT DIAGNOSTIC AGENTS WITHOUT PHOTOTOXICITY
Author(s) -
Takemura Takeshi,
Nakajima Susumu,
Sakata Isao
Publication year - 1994
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1994.tb05049.x
Subject(s) - phototoxicity , fluorescence , derivative (finance) , chemistry , manganese , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , in vitro , physics , optics , economics , financial economics
In order to develop tumor‐localizing fluorescent diagnostic agents without phototoxicity, various heterodimers linked by some spacers between a chlorine derivative and its Mn or Cu complex were synthesized. The representative agent of them was named HAT‐D01 and has a molecular formula of m ‐phthalyl‐{[13,17‐bispropanoic acid‐3‐ethenyl‐8‐formylethylidene‐7‐hydroxy‐2,7,12,18‐tetramethyl‐porphyrinate]‐manganese (III)}‐[3′‐ethenyl‐8′‐formylethylidene‐7′‐hydroxy‐2′,7′, 12′, 18′‐tetramethyl‐porphine‐13′, 17′‐bispropanoyl aspartic acid]‐bishydrazone.