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LIGHT‐MEDIATED CYCLIZATION OF (E)‐3‐(5‐[6‐HYDROXY‐7‐METHOXY] BENZOFURANYL)PROPENOIC ACID, A WATER‐SOLUBLE PRECURSOR OF 8‐METHOXYPSORALEN
Author(s) -
Mohammad Taj,
Morrison Harry
Publication year - 1994
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1994.tb05029.x
Subject(s) - chemistry , photodissociation , psoralen , photochemistry , medicinal chemistry , methoxsalen , water soluble , stereochemistry , organic chemistry , biochemistry , dna , psoriasis , medicine , dermatology
The title compound is a stable, water‐soluble “pro‐drug” for 8‐methoxypsoralen, which converts to psoralen upon photolysis with UVA light. The process involves the photolytic formation of a cis isomer that lactonizes in a dark reaction.