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LIGHT EMISSION ACCOMPANIES OXYGEN UPTAKE DURING THE PEROXIDATIVE METABOLISM OF TETRACYCLINES
Author(s) -
Gillo Virginia E.,
Cilento Giuseppe
Publication year - 1993
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1993.tb09588.x
Subject(s) - hydrogen peroxide , chemistry , tetracycline , peroxidase , oxygen , chlortetracycline , chemiluminescence , metabolism , horseradish peroxidase , reactive oxygen species , yield (engineering) , light emission , photochemistry , quantum yield , biochemistry , organic chemistry , enzyme , antibiotics , materials science , physics , optoelectronics , quantum mechanics , metallurgy , fluorescence
— Tetracycline molecules offer several sites for peroxidative metabolism of the type known to lead to oxygen consumption and electronic cxcitation. Accordingly, when tetracycline and chlortetracycline were exposed to horseradish peroxidase in the presence of hydrogen peroxide, oxygen was taken up and light emission was observed. The overall quantum yield ofchemiluminescencc is on the order of 10 6 , but that of chemiexcitation may be orders of magnitude higher as suggested by studies of sensitized emission. Given the widespread distribution of peroxidases, the formalion of highly reactive metabolites of tetracycline may have biological importance.