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PHOTOSENSITIZATION WITH BACTERIOCHLORINS
Author(s) -
Kessel David,
Smith Kevin M.,
Pandey R. K.,
Shiau F.Y.,
Henderson Barbara
Publication year - 1993
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1993.tb09549.x
Subject(s) - photodynamic therapy , in vivo , chemistry , biophysics , cancer research , medicine , biology , organic chemistry , microbiology and biotechnology
— Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wavelength of irradiation and tumor/skin distribution. Efficacy was correlated with circulating plasma levels of the different sensitizers but not with the photodynamic therapy response in cell culture.