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ENHANCED RESPONSE TO DAUNOMYCIN OF NORMAL, TUMOR AND METASTATIC CELL LINES via DRUG PHOTO ACTIVATION
Author(s) -
Andreoni Alessandra,
Colasanti Alberto,
Kisslinger Annamaria,
Mastrocinque Mlchele,
Portella Giuseppe,
Riccio Patrizia,
Roberti Giuseppe
Publication year - 1993
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1993.tb09223.x
Subject(s) - drug , cancer research , drug response , pharmacology , cell culture , chemistry , tumor cells , medicine , biology , genetics
— We have compared the cytotoxicity of daunomycin in vitro to highly differentiated normal epithelial cells (Fisher rat thyroid cells, FRTL‐5) and to two neoplastic cell lines, a thyroid carcinoma (TK‐6) and its lung metastasis (MPTK‐6). Whereas the cell lines are equally sensitive to the drug in the dark, if irradiated during incubation with daunomycin (86 J/cm 2 at 488 nm), they become more and differently sensitive. Namely, the drug doses producing 50% mortality decrease by factors of about 22, 28 and 16 for FRTL‐5, TK‐6 and MPTK‐6 cell lines, respectively. This result correlates with differences in drug uptake and resistance observed in the normal and neoplastic cell lines.