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DIFFERENTIAL EXPRESSION OF PYRIMIDINE DIMER‐BINDING PROTEINS IN NORMAL AND UV LIGHT‐TREATED VERTEBRATE CELLS
Author(s) -
McLenigan Mary,
Levine Arthur S.,
Protić Miroslava
Publication year - 1993
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1993.tb02932.x
Subject(s) - vertebrate , dimer , pyrimidine dimer , differential (mechanical device) , chemistry , biophysics , pyrimidine , microbiology and biotechnology , biology , biochemistry , physics , gene , organic chemistry , dna repair , thermodynamics
— The expression of UV damage‐specific DNA‐binding proteins was examined in various phylogenetically distant species with differing DNA repair phenotypes. Two distinct constitutive DNA‐binding activities, one specific for cyclobutane pyrimidine dimers and the other for non‐cyclobutane dimer photoproducts, were detected. The expression of these binding activity was found to be variable throughout the animal kingdom: cold‐blooded vertebrastes show a constitutive cyclobutance dimer‐binding activity excusively, and primates reveal only non‐cyclobutane expression (rather than the constitutive presence)of these UV damage‐specific DNA‐binding activities after UV traeatment correlate with the cell's capacity for DNA repair. In addition, cyclobutane pyrimidine dimer‐binding activities could be detected only in cells with eestablished photoreactivating activity