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THE PEROXIDATIVE METABOLISM OF TENOXICAM PRODUCES EXCITED SPECIES
Author(s) -
Nascimento Ana Lucia T. O.,
Escobar Jorge A.,
Cilento Giuseppe
Publication year - 1993
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1993.tb02301.x
Subject(s) - tenoxicam , chemistry , metabolism , excited state , biochemistry , physics , medicine , atomic physics , piroxicam , alternative medicine , pathology
Abstract The peroxidative metabolism of the nonsteroid anti‐inflammatory oxicams generates metabolites of the type expected from a dioxetane intermediae. Therefore, electronically excited metabolites may be expected. Consistent with this possibility, both direct and sensitized light emission are observed when tenoxicam is exposed to horseradish peroxidase or when added to leukocytes, where it undergoes a myeloperoxidase‐catalyzed aerobic oxidation. The similarity between peroxidative metabolism with concomitant oxygen uptake and photodegrdation brought about by singlet oxygen addition to the substrate is pointed out. As a whole, the results strengthen the view that electronically excited species should also be considered when analyzing the effect(s) of xenobiotics.