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THE ROLE OF LIPOPROTEINS IN THE DISTRIBUTION OF TIN ETIOPURPURIN (SnET2) IN THE TUMOR‐BEARING RAT
Author(s) -
Kessel David,
Garbo Greta M.,
Hampton James
Publication year - 1993
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1993.tb02290.x
Subject(s) - tin , bearing (navigation) , distribution (mathematics) , chemistry , biophysics , biology , mathematics , computer science , organic chemistry , mathematical analysis , artificial intelligence
The role of plasma lipoproteins in the distribution of the photosensitizing agent tin etiopurpurin (SnET2) was examined in male rats bearing the N ‐[4‐(5‐nitro‐2‐furyl)‐2‐thiazolyl]formamide‐induced tumor. Treatement with 17α‐ethinyl estradiol resulted in the depletion of total plasma cholesterol by > 70% and a corresponding decrease in plasma lipoproteins. To both control and estradiol‐treated animals, a therapeutic dose (1.5mg/kg) of SnET2 was administered and biodistribution measured 24 h later. Estradiol treatment was not associated with difference in the distribution of SnET2 to liver, skin or tumor, or in the pattern of affinity of SnET2 to plasma albumin and lipoprotein. These results indicate that a substantial decrease in circulating lipoprotein levels does not alter patterns of SnET2 biodistribution.