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CLEARANCE TIMES OF PORPHYRIN DERIVATIVES FROM MICE AS MEASURED BY in vivo FLUORESCENCE SPECTROSCOPY
Author(s) -
Kennedy J. C.,
Nadeau P.,
Petryka Z. J.,
Porrier R. H.,
Weagle G.
Publication year - 1992
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1992.tb08517.x
Subject(s) - hematoporphyrin , porphyrin , in vivo , fluorescence , chemistry , fluorescence spectroscopy , chlorin , spectroscopy , photochemistry , derivative (finance) , biophysics , photodynamic therapy , organic chemistry , biology , physics , quantum mechanics , financial economics , economics , microbiology and biotechnology
— The clearance times of 17 different porphyrin derivatives from SKH:HR‐1 mice have been measured using the technique of in vivo fluorescence spectroscopy. This technique monitors the in vivo porphyrin fluorescence observed from the external skin surface. Most hydrophilic porphyrin derivatives show relatively short clearance times, in the order of 2.5–6 h. The dicarboxylic acid porphyrins, proto‐, hydroxyethylvinyldeutero‐and hematoporphyrin IX have clearance times of 7.8, 12.2 and 14.7 h respectively. The mixture hematoporphyrin derivative has an intermediate clearance time of 12.6 h. N ‐methylated porphyrins show clearance times in the vicinity of 15–22 h. Monoaspartyl chlorin e 6 shows the longest clearance time of all porphyrin derivatives measured (30.3 h).