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OXIDATION OF PHOSPHATIDYLCHOLINE MEMBRANES BY SINGLET OXYGEN GENERATED IN THE GAS PHASE
Author(s) -
Eisenberg Walter C.,
Anand Jasbir,
Wang Shukun,
Stevenson Robert J.
Publication year - 1992
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1992.tb02186.x
Subject(s) - singlet oxygen , phosphatidylcholine , membrane , oxygen , chemistry , gas phase , phase (matter) , oxygen metabolism , biophysics , photochemistry , biochemistry , organic chemistry , biology , phospholipid
— Singlet‐oxygen ( 1 O 2 ) was generated in the gas phase by heterogeneous photosensitization and bubbled into suspensions of phosphatidylcholine (PC) liposomes. Lipid peroxidation and membrane lysis were observed, and were dependent on the 1 O 2 concentration and the degree of unsaturation of the liposome. An analysis based on large target diffusion theory indicates that approximately 5000, 2800, and 1600 interactions were required for the lysis of large dioleoylPC, dilinoleoylPC and dilinolenoylPC liposomes, respectively.