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In vivo EXPOSURE TO ULTRAVIOLET RADIATION ENHANCES PATHOGENIC EFFECTS OF MURINE LEUKEMIA VIRUS, LP‐BMS, IN MURINE ACQUIRED IMMUNODEFICIENCY SYNDROME
Author(s) -
Brotek Celestyn M.,
Shopp George M.,
Ryan Sharon L,
Gillespie Patricia M.,
Kusewitt Donna F.,
Rajagopalan M. S.,
Ley Kenneth D.,
Ley Ronald D.
Publication year - 1992
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1992.tb02162.x
Subject(s) - spleen , in vivo , virus , murine leukemia virus , leukemia , biology , virology , immunology , inoculation , ratón , microbiology and biotechnology
— LP‐BM5 murine leukemia virus (MuLV) induces an immunodeticiiency syndrome (MAIDS) in C57BL/6 mice which resembles immunological abnormalities observed in early stages of human AIDS. In our study, MAIDS virus‐infected mice were exposed to low doses of ultraviolet radiation (UVR) before and after virus inoculation and compared with MAIDS‐infected but not UVRcxposed mice. In all tested parameters (blood IgM levels; mitogenic responses to PHA. ConA, LPS and anti‐μ MLR antigenic response to SRBC, enlargement and histopathologic changes of the spleen) we observed the same trend: changes due to MAIDS infection were more pronounced in the UVR‐eposed group than in the unexposed group. Statistically significant differences between these two groups were Seen for mitogenic responses at two different time points after virus inoculation. These results demonstrate that in vivo UVR exposure enhances the immunosuppressive effects of a retroviral infection. UVR exposure may affect the progression of AIDS in a similar manner.