Premium
THE EFFECT OF THE ANTIHISTAMINE CIMETIDINE ON ULTRAVIOLET‐RADIATION‐INDUCED TUMORIGENESIS IN THE HAIRLESS MOUSE
Author(s) -
MATHESON MELISSA J.,
REEVE VIVIENNE E.
Publication year - 1991
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1991.tb08491.x
Subject(s) - cimetidine , hairless , antihistamine , histamine , antagonist , ultraviolet b radiation , period (music) , medicine , endocrinology , pharmacology , ultraviolet radiation , anesthesia , chemistry , receptor , biochemistry , radiochemistry , physics , acoustics
— This experiment investigated the effect on ultraviolet (UV) radiation‐induced tumorigenesis of feeding the histamine type 2 receptor antagonist, cimetidine, to Skh:HR mice. Cimetidine was fed to one group during a 70 day period of chronic UVR (5 day/week for 10 weeks), to a second group from the end of this period to the end of the experiment at 286 days and a third group was fed a control diet only throughout the experiment. Feeding mice cimetidine during the 70 day period of irradiation protected them against the later development of skin tumours.