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In vivo SPECTROPHOTOMETRIC EVALUATION OF NEOPLASTIC AND NON‐NEOPLASTIC SKIN PIGMENTED LESIONS–I. REFLECTANCE MEASUREMENTS
Author(s) -
MARCHESINI RENATO,
BRAMBILLA MARCO,
CLEMENTE CLAUDIO,
MANIEZZO MASSIMO,
SICHIROLLO ADELE E.,
TESTORI ALESSANDRO,
VENTUROLI DANIELE R.,
CASCINELLI NATALE
Publication year - 1991
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1991.tb08470.x
Subject(s) - reflectivity , integrating sphere , dermatology , actinic keratosis , melanoma , lentigo maligna , pathology , keratosis , medicine , absorption (acoustics) , chemistry , optics , cancer research , physics , basal cell
— Reflectance spectrophotometry from 400 to 800 nm on different cutaneous pigmented lesions, including primary and metastatic malignant melanoma, pigmented nevi, lentigo and seborrhoeic keratosis, has been performed by using an external integrating sphere coupled to a spectrophotometer. Measurements show that reflectance spectra of the different lesions manifest dissimilar patterns, particularly in the near IR region. Comparison of reflectance of nevi with that of malignant melanomas results in a highly significant difference ( P < 10 ‐6 ) between the two samples. Though interpretation of the specta remains difficult as a result of the complexity of the optical processes of scattering and absorption, our results suggest that a detailed analysis of the reflectance spectrum may give clinically useful information, and could be utilized as an aid in clinical diagnosis of cutaneous pigmented lesions, especially where malignant melanoma is concerned.