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PHOTOREACTIVITY OF 5‐GERANOXYPSORALEN AND LACK OF PHOTOREACTION WITH DNA
Author(s) -
MORLIÉRE P.,
BAZIN M.,
DUBERTRET L.,
SANTUS R.,
MELO T. SA E.,
HÜPPE G.,
HAIGLE J.,
FORLOT P.,
BERNARD A.
Publication year - 1991
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1991.tb08461.x
Subject(s) - furocoumarin , psoralen , chemistry , photochemistry , dna , quantum yield , triplet state , fluorescence , yield (engineering) , biophysics , biochemistry , organic chemistry , molecule , biology , physics , quantum mechanics , thermodynamics
— 5‐Geranoxypsoralen, commonly called bergamottin, a major furocoumarin contained in bergamot oil, is reported in vitro as a highly photoreactive psoralen. In ethanol, it exhibits quite a high triplet state quantum yield (≅0.37). The triplet state is involved in subsequent photochemistry which depends on the initial concentration and on the presence of oxygen. In contrast to most psoralens, absorption and fluorescence data suggest that 5‐geranoxypsoralen does not interact with DNA in the dark. No UVA‐induced interstrand cross‐links in DNA were shown.