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PHOTOSENSITIZATION IS REQUIRED FOR INACTIVATION OF EQUINE INFECTIOUS ANEMIA VIRUS BY HYPERICIN
Author(s) -
CARPENTER SUSAN,
KRAUS GEORGE A.
Publication year - 1991
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1991.tb03919.x
Subject(s) - hypericin , infectivity , equine infectious anemia , virus , virology , chemistry , viral replication , reverse transcriptase , biology , rna , pharmacology , biochemistry , gene
— Hypericin, a photoreactive polycyclic quinone, was found to dramatically reduce infectivity of cell‐free stocks of equine infectious anemia virus. However, the antiviral activity of hypericin was completely dependent on the presence of light. Short periods of photosensitization resulted in a partial loss of reverse transcriptase activity and complete inhibition of viral infectivity. These results suggest that the photodynamic effect of hypericin interferes with more than one stage in the virus replication cycle.