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DO PYRIMIDINE DIMER YIELDS CORRELATE WITH ERYTHEMA INDUCTION IN HUMAN SKIN IRRADIATED in situ WITH ULTRAVIOLET LIGHT (275–365 nm)?
Author(s) -
HACHAM H.,
FREEMAN S. E.,
GANGE R. W.,
MAYTUM D. J.,
SUTHERLAND J. C.,
SUTHERLAND B. M.
Publication year - 1991
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1991.tb03671.x
Subject(s) - pyrimidine dimer , erythema , dimer , human skin , ultraviolet , irradiation , ultraviolet radiation , photochemistry , radiation , dermatology , dna , wavelength , chemistry , materials science , optics , dna damage , optoelectronics , biology , medicine , radiochemistry , physics , biochemistry , genetics , organic chemistry , nuclear physics
Abstract— Ultraviolet radiation produces erythema in human skin, and damages the DNA of living cells in skin. Previous work showed that broad‐band UV‐B (290–320 nm) radiation produced higher levels of cyclobutyl pyrimidine dimers in DNA of individuals with high UV‐B sensitivity (low minimal erythema dose) than in subjects of low UV‐B sensitivity [Freeman et al. (1986) J. Invest. Dermatol. , 86 , 34–36]. We examined the relationship between erythema induction and dimer yields in DNA of human skin irradiated in situ with narrow band radiation spanning the wavelength range 275–365 nm. We find that, in general, higher dimer yields are produced per incident photon in volunteers with higher susceptibility to erythema induced by radiation of the same wavelength.