Premium
CHARACTERIZATION OF THE (6‐4) PHOTOPRODUCT OF 2′‐DEOXYCYTIDYLYL‐(3′‐>5′)‐THYMIDINE AND OF ITS DEWAR VALENCE ISOMER
Author(s) -
DOUKI T.,
VOITURIEZ L.,
CADET J.
Publication year - 1991
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1991.tb03631.x
Subject(s) - chemistry , deamination , aqueous solution , valence (chemistry) , thymidine , pyrimidine , irradiation , alkali metal , photochemistry , stereochemistry , medicinal chemistry , organic chemistry , dna , biochemistry , physics , nuclear physics , enzyme
— Far‐UV irradiation of dCpT in aqueous solution was found to generate the corresponding pyrimidine (6‐4) pyrimidone photoadduct and the related Dewar valence isomer. The two photoproducts of dCpT were found to undergo deamination in aqueous solution, giving rise to the corresponding dUpT derivatives at a relatively slow rate. It was also shown that the Dewar isomer is much more alkali‐labile than its (6‐4) precursor.