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ACTION SPECTRA OF THE ANTILEUKEMIC and ANTIVIRAL ACTIVITIES OF MEROCYANINE 540
Author(s) -
O'Brien J. M.,
Singh R. J.,
Feix J. B.,
Kalyanaraman B.,
Sieber F.
Publication year - 1991
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1991.tb02101.x
Subject(s) - action (physics) , spectral line , chemistry , virology , biology , physics , astronomy , quantum mechanics
Action spectra of the antileukemic and antiviral activities of merocyanine 540 (MC540) were determined using L1210 leukemia cells and human Herpes simplex virus type 1. The major peak of both action spectra aligned closely with the absorption spectrum of membrane‐bound dye monomer, and by implication, the action spectrum of 1 O 2 generation. These results are compatible with the notion that the antileukemic and antiviral activities of MC540 are primarily attributable to membrane‐bound monomer and at least in part mediated by 1 O 2 .