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STRUCTURAL ELUCIDATION OF THE 8‐METHOXYPSORALEN OXIDIZED PRODUCT THAT INHIBITS THE CHEMOTACTIC ACTIVITY OF POLYMORPHONUCLEAR NEUTROPHILS TOWARD ANAPHYLATOXIN C5a
Author(s) -
Mizuno Nobuyuki,
Esaki Kenji,
Sakakibara Jinsaku,
Murakami Nobutoshi,
Nagai Shinichi
Publication year - 1991
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1991.tb02077.x
Subject(s) - chemotaxis , anaphylatoxin , chemistry , granulocyte , immune system , biochemistry , stereochemistry , immunology , receptor , complement system , biology
The chemical structure of the 8‐methoxypsoralen oxidized product that inhibits the chemo‐tactic activity of anaphylatoxin C5a was determined to be 2,3‐dihydro‐2,9‐dimethoxy‐3‐hydroxy‐7‐oxo‐7H‐futo[3,2‐g][l]benzopyran. Its minimal concentration required to obtain the maximum inhibition of C5a des Arg (1 times 10 −8 M ) chemotactic activity is 2.5 times 10 −8 M. Bioactivity of this substance was maintained for 2 weeks, stored in a dark room at room temperature under aerobic conditions. There is a possibility that this substance may be useful in the treatment of immune complex diseases.