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PHOTOCHEMICAL ONE‐POT SYNTHESIS OF VINBLASTINE and VINCRISTINE
Author(s) -
Pennanen S.,
Huhtikangas A.
Publication year - 1990
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1990.tb01959.x
Subject(s) - vinblastine , vincristine , chemistry , combinatorial chemistry , photochemistry , medicine , chemotherapy , cyclophosphamide
The naturally occurring cytostatic dimer alkaloids vinblastine 1 and vincristine 2 were photochemically synthesized in slightly acidic aqueous solution from the monomer alkaloids catharan‐thine 3 and vindoline 4 . Multi‐centre reactions should obviously be involved and some of the principal photochemistry‐associated phenomena here discussed are quite likely to be characteristic even to the biosynthetic reactions yielding vinblastine 1 and vincristine 2 in the cells of Catharanthus roseus.