Premium
DEPOLARIZATION OF MOUSE MYELOMA CELL MEMBRANES DURING PHOTODYNAMIC ACTION
Author(s) -
Specht K. G.,
Rodgers M. A. J.
Publication year - 1990
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1990.tb01717.x
Subject(s) - depolarization , membrane , multiple myeloma , action (physics) , cell , chemistry , biophysics , microbiology and biotechnology , biology , biochemistry , physics , immunology , quantum mechanics
— The effect of photodynamic action on plasma membranes was examined using a fluorescent potentiometric indicator [di‐SBA‐C 2 (3)] to measure alterations in the plasma membrane potential of mouse myeloma cells treated with zinc phthalocyanine sulfonate and light. Plasma membrane depolarization was observed to be an early event in photodynamic action, showing both photosensitizer concentration and light dose dependence. Depolarization occurred while membrane integrity was retained and appears to be an early event preceding cell death.