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THE PHOTOCHEMISTRY OF ACETYL‐SUBSTITUTED AROYL AZIDES: THE DESIGN OF PHOTOLABELING AGENTS FOR INERT SITES IN HYDROPHOBIC REGIONS
Author(s) -
Melvin T.,
Schuster Gary B.
Publication year - 1990
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1990.tb01697.x
Subject(s) - chemistry , azide , electrophile , reactivity (psychology) , combinatorial chemistry , photochemistry , molecule , derivative (finance) , functional group , organic chemistry , catalysis , polymer , alternative medicine , pathology , financial economics , economics , medicine
— The photochemistry, photophysics and hydrolytic stability of three substituted aroyl azides were investigated. The azides were selected as model compounds for potential photolabeling agents based on the extreme electrophilic reactivity of aroylnitrenes. Each of the azides studied is a derivative of benzoyl azide containing an acyl group to act as an internal triplet sensitizer and an additional functional group useful for linking the azide to a site‐selecting probe molecule. The findings show that benzoyl azides containing the three substituents in a 1,3,5‐pattern might be useful for labeling of lipophilic molecules.