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In vitro PHOTOSENSITIZATION WITH A BENZOPORPHYRIN DERIVATIVE
Author(s) -
KESSEL DAVID
Publication year - 1989
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1989.tb08426.x
Subject(s) - phototoxicity , hematoporphyrin , photosensitizer , in vitro , chemistry , photodynamic therapy , biophysics , absorbance , membrane , derivative (finance) , photochemistry , biochemistry , chromatography , organic chemistry , biology , economics , financial economics
Abstract Biophysical and photobiological properties of two benzoporphyrin derivatives were examined. These dyes exhibit substantial absorbance in the red, and are potent photosensitizers in vitro. After brief (0.5 h) incubations, phototoxicity was more closely correlated with membrane than with mitochondrial photodamage. Affinity of these dyes toward plasma lipoproteins are consistent with a mode of localization via the LDL‐mediated mechanism utilized by the hematoporphyrin‐derived product, HPD.