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GLUCOSE ADMINISTRATION AUGMENTS IN VIVO UPTAKE AND PHOTOTOXICITY OF THE TUMOR‐LOCALIZING FRACTION OF HEMATOPORPHYRIN DERIVATIVE
Author(s) -
Thomas James P.,
Girotti Albert W.
Publication year - 1989
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1989.tb04102.x
Subject(s) - hematoporphyrin , phototoxicity , in vivo , rhabdomyosarcoma , chemistry , galactose , pharmacology , biochemistry , medicine , in vitro , photodynamic therapy , biology , pathology , sarcoma , microbiology and biotechnology , organic chemistry
Rhabdomyosarcoma tumors in rats made hyperglycemic by multiple injections of glucose exhibited a transient decrease in pH and an increased ability to accumulate derivatives of hemato‐porphyrin (HPD). Photoradiation of tumors in glucose/HPD‐treated animals produced a greater cell kill than in galactose/HPD‐treated controls. A therapeutic benefit of glucose administration in conjunction with HPD‐phototherapy is suggested.