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SANGUINARINE, A PHOTOTOXIC H 2 O 2 ‐PRODUCING ALKALOID
Author(s) -
Tuveson R. W.,
Larson Richard A.,
Marley Karen A.,
Wang Guirong,
Berenbaum May R.
Publication year - 1989
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1989.tb02903.x
Subject(s) - sanguinarine , phototoxicity , trichoplusia , alkaloid , catalase , chemistry , escherichia coli , biochemistry , biology , stereochemistry , botany , enzyme , in vitro , larva , gene , noctuidae
— Sanguinarine chloride, a quaternary salt of a benzophenanthrene alkaloid, was phototoxic to catalase‐deficient strains of Escherichia coli but not to Trichoplusia ni (cabbage looper moth larvae), an insect with high levels of catalase activity. Chemical analyses confirm that sanguinarine is an efficient producer of H 2 O 2 . This differential toxicity suggests that the mode of phototoxic action involves production of H 2 O 2 which could be detoxified in many organisms by catalase.