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PSORALEN AND THE SUPPRESSION OF MELATONIN SECRETION BY BRIGHT LIGHT
Author(s) -
Souetre E.,
Salvati E.,
Lacour J. C.,
Belugou J. L.,
Krebs B.,
Ortonne J. P.,
Darcourt G.
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb08847.x
Subject(s) - melatonin , darkness , psoralen , endocrinology , medicine , plasma levels , human plasma , secretion , methoxsalen , plasma concentration , chemistry , biology , biochemistry , chromatography , botany , immunology , dna , psoriasis
— Melatonin plasma levels were analyzed in 21 normal human subjects placed in darkness frm 7:30 p.m. to 11 p.m. and then submitted to bright light exposure (over 1500 lx) to 2 a.m. 5‐Methoxypsoralen (5‐MOP) was orally (40 mg) given to 11 of those subjects at 9 p.m. In darkness, melatonin plasma levels increased slightly in untreated subjects and dramatically in subjects having received 5‐MOP. Under bright light exposure, the melatonin plasma levels were significantly reduced in drug free controls but not in treated subjects.