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A NEW BIOLOGICAL TARGET OF FUROCOUMARINS: PHOTOCHEMICAL FORMATION OF COVALENT ADDUCTS WITH UNSATURATED FATTY ACIDS
Author(s) -
Specht Kathleen G.,
Kittler Leonhard,
Midden W. Robert
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb08841.x
Subject(s) - chemistry , adduct , furocoumarins , furocoumarin , photochemistry , quantum yield , mass spectrometry , yield (engineering) , covalent bond , methanol , organic chemistry , fluorescence , chromatography , dna , biochemistry , physics , materials science , quantum mechanics , metallurgy
— Furocoumarins, potent skin therapy and tanning agents, form covalent adducts in a photochemical reaction with unsaturated fatty acids. These adducts and the chemical kinetics of their formation have been characterized by chromatography, isotopic tracers, electronic absorbance and fluorescence spectroscopy and mass spectrometry. Adduct formation does not require oxygen. The quantum yield of adduct formation in ethanol or methanol‐water solutions is comparable to the quantum yield for formation of furocoumarin‐thymine adducts in DNA.