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PHOTODYNAMIC SENSITIZERS FROM CHLOROPHYLL:PURPURIN–18 AND CHLORIN p 6
Author(s) -
Hoober J. Kenneth,
Sery Theodore W.,
Yamamoto Nobuto
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb02867.x
Subject(s) - chlorin , photodynamic therapy , chemistry , chlorophyll a , covalent bond , chlorophyll , pheophorbide a , photochemistry , biochemistry , organic chemistry
— Two easily prepared derivatives of chlorophyll,purpurin–18 and chlorin p 6 , are potent sensitizers of cell killing by low‐intensity red light. The internal anhydride group inpurpurin–18 provides the potential of covalently linking in one step the chlorin to cell targeting agents such as antibodies.