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ACCUMULATION OF PORPHYRINS IN CELLS: INFLUENCE OF HYDROPHOBICITY AGGREGATION AND PROTEIN BINDING
Author(s) -
Oenbrink Georg,
Jurgenlimke Petra,
Gabel Detlef
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb02844.x
Subject(s) - chemistry , chinese hamster , octanol , chinese hamster ovary cell , porphyrin , biophysics , cell , hamster , partition coefficient , albumin , plasma protein binding , distribution (mathematics) , biochemistry , in vitro , chromatography , microbiology and biotechnology , biology , receptor , mathematical analysis , mathematics
— For a variety of chemically defined, synthetic and natural porphyrins, the tendency for self aggregation, binding to serum albumin, distribution coefficient betweenoctanol–1 and water and uptake in V79 Chinese hamster cells have been determined. A strong correlation was found between cell uptake and distribution into octanol. None of the other factors could be correlated with cell uptake. These observations might have an impact on the use of porphyrins in photodynamic and boron neutron capture therapy of tumors.