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A NEW ELECTRONIC ABSORBANCE BAND IN CONCENTRATED AQUEOUS SOLUTIONS OF HEMATOPORPHYRIN IX DETECTED BY PHOTOACOUSTIC SPECTROSCOPY
Author(s) -
Pottier R.,
Lachaine A.,
Pierre M.,
Kennedy J. C.
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb02763.x
Subject(s) - photoacoustic spectroscopy , hematoporphyrin , aqueous solution , absorbance , chemistry , sodium dodecyl sulfate , porphyrin , spectroscopy , q band , analytical chemistry (journal) , photochemistry , chromatography , organic chemistry , photodynamic therapy , physics , quantum mechanics , astronomy
— Photoacoustic (PA) spectroscopy reveals a new electronic transition in concentrated aqueous solutions of hematoporphyrin IX (Hp). This new band has a maximum near 440 nm. Its intensity is sensitive to pH, concentration, PA chopping frequency, and the presence of sodium dodecyl sulfate (SDS). Data presented support the assignment of this new band to a dimeric form of Hp. The pH effects on this new band are discussed in terms of their implications for the selective biodistribution of certain porphyrin‐based photochemotherapeutic agents.