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TYPES I AND II SENSITIZED PHOTOOXIDATION OF AMINOACID BY PHTHALOCYANINES: A FLASH PHOTOCHEMICAL STUDY
Author(s) -
Ferraudi G.,
Arguello G. A.,
Ali H.,
Lier J. E.
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb02761.x
Subject(s) - flash photolysis , chemistry , photochemistry , excited state , reaction rate constant , electron transfer , reactivity (psychology) , redox , phthalocyanine , photosensitizer , photodynamic therapy , photodissociation , kinetics , inorganic chemistry , organic chemistry , medicine , physics , alternative medicine , pathology , quantum mechanics , nuclear physics
— In connection with the use of red light‐photosensitizers for photodynamic therapy, the redox reactivity of excited metallophthalocyanines (M = Al, Ga) was investigated by flash photolysis in order to establish whether photooxidations proceed by Foote's mechanisms I or II. Aminoacids (tryptophan, tyrosine) were seen to function as electron transfer quenchers of the excited phthalocyanines with rate constants 10 7 k 10 4 M ‐1 s ‐1 . This was not the case of purines or ATP. The ability of the excited phthalocyanines to sensitize photooxidations by mechanisms I and II is discussed in terms of evaluated rate constants.