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THE EFFECT OF PHOTODYNAMIC THERAPY ALONE AND IN COMBINATION WITH MISONIDAZOLE OR X‐RAYS FOR MANAGEMENT OF A RETINOBLASTOMA‐LIKE TUMOUR †
Author(s) -
Wlnther J.,
Overgaard J.,
Ehlers N.
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb02746.x
Subject(s) - misonidazole , photodynamic therapy , retinoblastoma , radiosensitizer , irradiation , radiation therapy , in vivo , chemistry , cancer research , medicine , combination therapy , nuclear medicine , in vitro , biology , physics , biochemistry , microbiology and biotechnology , nuclear physics , organic chemistry , gene
— The effect of photodynamic therapy alone and combined with misonidazole or X‐rays has been investigated in an intraocular retinoblastoma‐like tumor. Tumour control rate was achieved up to 33% and depended both on the light energy doses and the Photofrin II doses. Misonidazole injected prior to light irradiation did not enhance the photodynamic therapy response, although the misonidazole was uptaken by the tumor tissue. The combination of X‐rays and photodynamic therapy demonstrated both in vivo and in vitro not more than a simple additive effect and there was no difference between X‐rays given before or after the light irradiation.