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HIGH LEVELS OF 4,5′,8‐TRIMETHYLPSORALEN PHOTOINDUCED FURAN‐SIDE MONOADDUCTS CAN BLOCK CROSS‐LINK REMOVAL IN NORMAL HUMAN CELLS
Author(s) -
Papadopoulo D.,
Averback D.,
Moustacchi E.
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb02733.x
Subject(s) - furocoumarin , furan , chemistry , block (permutation group theory) , photochemistry , stereochemistry , dna , organic chemistry , biochemistry , geometry , mathematics
— The induction and removal of DNA interstrand cross‐links (CL) was studied in normal human fibroblasts (1BR/3) using the highly photoreactive furocoumarin 4,5′,8‐trimethylpsoralen (TMP) in combination with monochromatic 365 nm and/or 405 nm radiation. We report that the presence of large amount of furan‐side monoadducts (MA f ) induced by TMP plus 365 nm radiation blocks CL incision. When the amount of MA f is reduced by their conversion into even more CL, incision of the cross‐links is more efficient.