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PHOTOSENSITIZATION OF NEOPLASTIC CELLS BY ANTHRAPYRAZOLES *
Author(s) -
Kessel David
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb02721.x
Subject(s) - singlet oxygen , cell culture , leukemia , chemistry , yield (engineering) , cell , microbiology and biotechnology , oxygen , cancer research , biophysics , biology , biochemistry , immunology , genetics , materials science , organic chemistry , metallurgy
— Three anthrapyrazoles were tested for their ability to photosensitize murine leukemia cells in culture. Photosensitization was correlated with singlet oxygen yield. A cell line which exhibits anthrapyrazole resistance was also photosensitized, but the resulting photodamage was substantially less than in the drug‐sensitive cell line. This result has implications with regard to repair mechanisms in drug sensitive vs resistant cells.