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POLYETHYLENE GLYCOL‐MODIFIED HEMATOPORPHYRIN AS PHOTOSENSITIZER
Author(s) -
Kodera Yoh,
Ajima Ayako,
Takahashi Katsunobu,
Matsushima Ayako,
Saito Yuji,
Inada Yuji
Publication year - 1988
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1988.tb02718.x
Subject(s) - hematoporphyrin , chemistry , polyethylene glycol , aqueous solution , photosensitizer , photochemistry , chloroform , polymer chemistry , organic chemistry , photodynamic therapy
— Hematoporphyrin, having two carboxylic groups, was coupled with α‐(3‐aminopropyl)‐ω‐methoxypoly(oxyethylene), PEG‐NH 2 , through acid‐amide bond formed with carbodtimide. PEG‐modified hematoporphyrin was readily soluble not only in neutral aqueous solution but also in organic solvents. Its absorption spectrum showed a sharp band at 376 nm in neutral aqueous solution and at 403 nm in benzene. Modified hematoporphyrin acted as a photosensitizer; imidazole and indole were photooxidized in organic solvents such as benzene or chloroform, and uric acid was also photooxidized in neutral aqueous solution.