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NON‐CLOTTABLE FIBRINOGEN BY PHOTOOXIDATION IN BLOOD PLASMA
Author(s) -
Yoshimoto Takayuki,
Saito Yuji,
Inada Yuji
Publication year - 1987
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1987.tb07398.x
Subject(s) - methylene blue , fibrinogen , chemistry , incandescent light bulb , thrombin , irradiation , blood proteins , oxygen , chromatography , photochemistry , biochemistry , blood plasma , biophysics , platelet , medicine , organic chemistry , biology , catalysis , physics , photocatalysis , nuclear physics
— Bovine blood plasma anticoagulated with acid‐citrate dextrose was irradiated with an incandescent lamp in the presence of methylene blue and oxygen. Thrombin‐induced clotting activity of plasma was rapidly reduced and was lost completely in only 10 min of irradiation. This is due to the very rapid photooxidation of fibrinogen regardless of the presence of other proteins.