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TUMOR DESTRUCTION IN PHOTODYNAMIC THERAPY
Author(s) -
Nelson J. Stuart,
Liaw L.H.,
Berns Michael W.
Publication year - 1987
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1987.tb04855.x
Subject(s) - photodynamic therapy , electron microscope , pathology , photosensitizer , tumor cells , chemistry , medicine , cancer research , optics , photochemistry , physics , organic chemistry
The effects of photodynamic therapy (PDT) on the tumor microvasculature in the first few hours after treatment was studied at the light microscope (LM) and electron microscope (EM) levels in DBA/2Ha mice bearing SMT‐F tumors. Animals received intraperitoneal injections of 10 mg kg − of Photofrin II and 24 h later tumors were treated with 100 J cm −2 of light (630 nm). Animals were sacrificed and their tumors removed at time 0, 30 min, 1, 2, 4, 8, 16 and 24 h after treatment. The results indicate that the effects of PDT are initially direct destruction of the microfibrils in the subendothelial zone of the tumor capillaries with subsequent tumor cell death secondary to hemorrhage and vascular collapse.