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BIOLOGICAL ACTIVITIES OF PHTHALOCYANINES–VII. PHOTOINACTIVATION OF V‐79 CHINESE HAMSTER CELLS BY SELECTIVELY SULFONATED GALLIUM PHTHALOCYANINES
Author(s) -
Brasseur Nicole,
Ali Hasrat,
Langlois Rejean,
Van Lier Johan E.
Publication year - 1987
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1987.tb04841.x
Subject(s) - gallium , chemistry , photochemistry , phthalocyanine , chloride , photosensitizer , hamster , chinese hamster , organic chemistry , in vitro , biochemistry , medicine
Gallium chloride phthalocyanines sulfonated to different degrees were tested for their ability to inactivate V‐79 Chinese hamster cells in the presence of red light. The mono‐ and disulfonated compounds were the most active whereas the tri‐ and tetrasulfonated complexes were completely void of photoactivity. In addition, large variations in photoactivity were observed among the four isomeric disulfonated derivatives with the most hydrophobic isomer exhibiting the highest photoactivity. Prolonged exposure to the disulfonated complex resulted in increased photosensitization. Complexing the dye with Al instead of Ga resulted in a slightly increased photosensitizing effect.