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ANTIVIRAL ACTIVITY OF MEROCYANINE 540
Author(s) -
Sieber Fritz,
O'Brien Jill M.,
Krueger Gregory J.,
Schober Sheri L.,
Burns William H.,
Sharkis Saul J.,
Sensenbrenner Lyle L.
Publication year - 1987
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1987.tb04836.x
Subject(s) - merocyanine , haematopoiesis , viral envelope , bone marrow , membrane , chemistry , biophysics , microbiology and biotechnology , virus , biology , stem cell , biochemistry , virology , immunology , photochemistry , photochromism
Simultaneous exposure to the lipophilic dye merocyanine 540 (MC 540) and white light inactivates several enveloped viruses. The same treatment appears to have little or no effect on pluripotent hematopoietic stem cells, mature red cells, and mature leukocytes. At least some components of the clotting system are spared, too. The molecular basis of the virucidal effect of MC 540 and light is not yet completely understood. Based on what is known about the interactions of MC 540 with cells and artificial membranes, it seems likely that MC 540 binds to and damages the viral envelope. MC 540‐mediated photosensitization may have implications for the sterilization of bone marrow and blood products, the preparation of vaccines, and selected areas of antiviral therapy.