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STUDIES ON THE STRUCTURE OF PORPHYRINS CONTAINED IN PHOTOFRIN® II
Author(s) -
Dougherty Thomas J.
Publication year - 1987
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1987.tb04815.x
Subject(s) - aluminum hydride , hydrolysis , chemistry , ether , lithium (medication) , hydride , proton , porphyrin , acid hydrolysis , combinatorial chemistry , inorganic chemistry , organic chemistry , ion , metal , medicine , physics , quantum mechanics , endocrinology , methoxide
Using three methods to attempt to identify the presence of ester‐linked porphyrins in Photofrin® II, lithium aluminum hydride reduction, basic hydrolysis and proton NMR. it can be concluded that 40‐50% of such linkages are present. The majority of the remaining material is cleaved by acid hydrolysis, which is consistent with the ether structure proposed earlier. earlier.