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INDUCTION OF SISTER CHROMATID EXCHANGES IN Allium cepa MERISTEMATIC CELLS EXPOSED TO meso‐ TETRA(4‐PYRIDYL) PORPHINE and HEMATOPORPHYRIN PHOTORADIATION
Author(s) -
HAZEN M. J.,
VILLANUEVA A.,
STOCKERT J. C.
Publication year - 1987
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1987.tb04796.x
Subject(s) - hematoporphyrin , sister chromatids , chromatid , chemistry , tetra , sister chromatid exchange , porphyrin , allium , photochemistry , microbiology and biotechnology , chromosome , medicinal chemistry , dna , biology , biochemistry , photodynamic therapy , botany , organic chemistry , gene
The photodynamic effect of two porphyrin derivatives, meso‐tetra (4‐pyridyl)porphine (T 4 PyP) and hematoporphyrin (HP), and activating red light (647.1 nm) was tested, measuring the number of sister chromatid exchanges induced by this treatment in Allium cepa chromosomes. A significant increase in the frequencies of sister chromatid exchanges was observed when chromosomes substituted with 5‐bromo‐2′‐deoxyuridine were treated for 4 h (G 1 of the second cycle of division) with T 4 PyP or HP followed by an irradiation with red light for 5 min.