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LOSS OF PHOTOREVERSIBILITY OF SUNBURN CELL INDUCTION IN Monodelphis domestica
Author(s) -
Ley Ronald D.,
Applegate Lee A.
Publication year - 1987
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1987.tb04773.x
Subject(s) - pyrimidine dimer , sunburn , photolyase , monodelphis domestica , biology , ultraviolet radiation , epidermis (zoology) , chemistry , dna repair , opossum , biochemistry , dna , anatomy , dermatology , medicine , radiochemistry
Exposure of the South American opossum, Monodelphis domestica , to ultraviolet radiation (UVR) resulted in the formation of sunburn cells (SBCs) in the epidermis. If, however, the UVR was immediately followed by an exposure to photoreactivating light, which reversed ∼ 95% of the UVR‐induced pyrrolidine dimers in epidermal DNA, the appearance of SBCs was suppressed by ∼ 90%. Delaying the photoreactivation (PR) treatment resulted in a progressive loss with time in the capacity of the PR treatment to suppress SBC induction. PR treatment administered 12 h after UVR exposure resulted in only an ∼ 11% suppression of SBC formation even though ∼ 97% of the remaining pyrimidine dimers were repaired by the PR exposure.