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Monodelphis domestica: A NEW ANIMAL MODEL FOR STUDIES IN PHOTODERMATOLOGY *
Author(s) -
Ley Ronald D.
Publication year - 1987
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1987.tb04760.x
Subject(s) - monodelphis domestica , pyrimidine dimer , opossum , photolyase , biology , marsupial , biophysics , dna , zoology , microbiology and biotechnology , dna damage , genetics , anatomy , dna repair
The ability to photoreverse pyrimidine dimers in DNA of the South American opossum Monodelphis domestica provides a powerful tool with which to probe the role of pyrimidine dimers in ultraviolet radiation (UVR)‐induced histopathologic changes of the skin of this mammal. We have observed that post‐UVR exposure to photoreactivation light not only reversed pyrimidine dimers in epidermal DNA, but also suppressed the capacity of UVR to induce macroscopic and microscopic changes in the skin of M. domestica.