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PHOTOSENSITIZATION BY ANTITUMOR AGENTS—1. PRODUCTION OF SINGLET OXYGEN DURING IRRADIATION OF ANTHRAPYRAZOLES WITH VISIBLE LIGHT
Author(s) -
Reszka Krzysztof,
Tsoungas Petros G.,
Lown J. William
Publication year - 1986
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1986.tb09526.x
Subject(s) - singlet oxygen , sodium azide , photochemistry , oxygen , chemistry , irradiation , visible spectrum , intramolecular force , acceptor , electron paramagnetic resonance , materials science , stereochemistry , nuclear magnetic resonance , organic chemistry , optoelectronics , physics , nuclear physics , condensed matter physics
— Oxygen consumption, photoinduced by visible light, and sensitized by novel anthrapyrazole antitumor agents has been observed. Generation of singlet oxygen upon irradiation of ethanolic solutions of the drugs with visible light (480–520 nm) was demonstrated using a specific 1 O 2 acceptor, 2.5‐dimethylfuran and a quencher, sodium azide. An electron paramagnetic resonance method was employed to measure the rate of oxygen consumption. Significant differences were found in the sensitizing properties among the anthrapyrazoles studied. Intramolecular hydrogen bonding within the chro‐mophore is one of the structural factors that determine the efficacy of a given anthrapyrazole in 1 O 2 generation