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ACUTE EFFECTS OF LOW‐FLUENCE ULTRAVIOLET LIGHT ON HUMAN T‐LYMPHOCYTE SUBSETS
Author(s) -
Mcgrath Hugh,
WILSON Wendella,
Scopelitis Eve
Publication year - 1986
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1986.tb05638.x
Subject(s) - ultraviolet , ultraviolet light , in vivo , cytotoxic t cell , lymphocyte , ultraviolet irradiation , peripheral blood mononuclear cell , irradiation , ultraviolet b , in vitro , sunlight , biology , immunology , microbiology and biotechnology , chemistry , medicine , genetics , physics , photochemistry , dermatology , optics , nuclear physics
‐The acute effects of low‐fluence ultraviolet light, primarily between wavelengths 280 and 320 nm (ultraviolet B) on T‐lymphocyte subsets were assessed in virro and in vivo by quantitative cytofluorometric analysis. In virro, 90J/m 2 of ultraviolet irradiation of human mononuclear cells produced a significant increase in the OKT4 (helper‐inducer)/OKT8 (suppressor‐cytotoxic) ratio (P>0.008), due primarily to a decrease in the OKT8 subset. In vivo, 24 h after whole‐body UV irradiation of human subjects with one half of a minimal erythemal dose of ultraviolet B the OKT4/OKT8 ratios again increased (P > 0.002), again with somewhat greater effects on the OKT8 subset. These results indicate that suberythemal exposure to UV light increases OKT4/OKT8 ratios in normal human subjects because of differential effects on lymphocyte subsets. They suggest that casual exposure to sunlight mediates immunologic changes in normal human subjects.