Premium
SENSITIVITY OF MOUSE SKH:HR‐2 TO ULTRAVIOLET LIGHT: MOUSE PIGMENTATION MODEL
Author(s) -
Warren Raphael
Publication year - 1986
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1986.tb05589.x
Subject(s) - ultraviolet , melanocyte , ultraviolet a , ultraviolet light , tyrosinase , melanin , pigment , dermatology , chemistry , biology , biochemistry , medicine , enzyme , materials science , photochemistry , cancer research , optoelectronics , melanoma , organic chemistry
— The mouse Skh:HR‐2 has been reported to be sensitized to ultraviolet light and become pigmented. Using three independent parameters associated with pigmentation. we have examined the ability of the mouse to become pigmented. The methods utilized were spectroscopic (skin color). histological (melanocyte density and epidermal thickness), and biochemical (tyrosinase activity). Following a two‐week ultraviolet exposure, the mice were pigmented with the degree of pigment change related to the ultraviolet dose administered. Perturbations in skin color, epidermal thickness, melanocyte density, and tyrosinase activity were recorded. Mice were also examincd for their response to tyrosinc applied topically following each ultraviolet exposure. With the exccption of epidermal thickness. all the pigmentation parameters were accentuated when compared to results from ultraviolet exposure alone.