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ULTRAVIOLET HYPERSENSITIVITY OF COCKAYNE SYNDROME LYMPHOBLASTOID LINES—THE EFFECTS OF EXOGENOUS β‐NICOTINAMIDE ADENINE DINUCLEOTIDE
Author(s) -
Otsuka Fujio,
Kukita Atsushi
Publication year - 1986
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1986.tb05534.x
Subject(s) - nad+ kinase , nicotinamide adenine dinucleotide , xeroderma pigmentosum , cockayne syndrome , nicotinamide , lymphoblast , chemistry , microbiology and biotechnology , biology , biochemistry , cell culture , enzyme , dna , dna repair , genetics
Four Cockayne Syndrome (CS) lymphoblastoid lines were tested for the lethal effects of UV radiation (254 nm) with or without addition of exogenous β‐nicotinamide adenine dinucleotide (β‐NAD + ) to their culture medium. Two of them exhibited a small but significantly increased resistance to UV radiation when β‐NAD + was added to the culture. However, their UV sensitivity after β‐NAD + addition was still much greater than that of normal control lines. Normal control lymphoblastoid lines and those from complementation group A and group C of xeroderma pigmentosum (XP) did not reveal any differences in post‐UV sensitivity after the addition of exogenous β‐NAD + . Thus the abnormal response to the lethal effects of UV radiation of CS lymphoblastoid lines could not be rectified by β‐NAD + addition. However, β‐NAD + does appear to play some partial role in reducing the high UV sensitivity of some CS lymphoblastoid lines.