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TIN‐PROTOPORPHYRIN: A POTENT PHOTOSENSITIZER OF BILIRUBIN DESTRUCTION
Author(s) -
McDonagh Antony F.,
Palma Lucita A.
Publication year - 1985
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1985.tb08940.x
Subject(s) - photosensitizer , phototoxicity , protoporphyrin , in vivo , chemistry , bilirubin , protoporphyrin ix , in vitro , photodynamic therapy , pharmacology , biophysics , biochemistry , photochemistry , medicine , biology , endocrinology , porphyrin , organic chemistry , microbiology and biotechnology
— Tin(IV)‐protoporphyrin chloride, a proposed chemotherapeutic agent for prevention of neonatal hyperbilirubinemia, is a potent photosensitizer of bilirubin destruction in vitro at visible wavelengths (410, 540, 580 nm). We speculate that the drug may have phototoxic effects in vivo if it accumulates in light‐accessible tissues.