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PHOTO‐CIDNP IN NUCLEIC ACID BASES AND THEIR NUCLEOTIDES INDUCED BY CHLORPROMAZINE AND ANALOGS
Author(s) -
Marko J.,
Vermeersch G.,
FebvayGarot N.,
LablacheCombier A.
Publication year - 1985
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1985.tb08934.x
Subject(s) - chemistry , nucleotide , cidnp , phenothiazine , guanine , chlorpromazine , nucleic acid , purine , stereochemistry , biochemistry , radical , pharmacology , biology , gene , enzyme
— [ 1 H] and [ 13 C]photo‐CIDNP of a mixture of aqueous chlorpromazine (CPZ) and different pyrimidine and purine bases and nucleotides show polarizations of the starting material excepted when guanine or its nucleotide were used. These polarizations can be explained by means of an electron transfer mechanism from CPZ to the bases. Similar effects are observed with other phenothiazine drugs of the CPZ class. The lonely difference consists in the intensity of the polarized signals of the bases. We try to correlate this intensity with the phototoxic potency of the drug.